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If you are or have been addicted to opioids, alcohol, prescription drugs or illegal drugs;
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feel that you need to take more capsules to get the same level of pain relief, this may mean that you are becoming tolerant to the effects of this medicine or becoming dependent on it. Talk to your prescriber who will discuss your treatment and may change your dose or switch to an alternative pain reliever;
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have myxedema (a thyroid disorder associated with dryness, coldness and swelling or swelling of the skin affecting the face and limbs);
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have low blood volume (hypovolaemia). This can occur due to severe external or internal bleeding, severe burns, excessive sweating, severe diarrhea or vomiting ;
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